Modeling of Identity-by-Descent Processes Along a Chromosome Between Haplotypes and Their Genotyped Ancestors
نویسندگان
چکیده
منابع مشابه
Modeling of identity-by-descent processes along a chromosome between haplotypes and their genotyped ancestors.
Identity-by-descent probabilities are important for many applications in genetics. Here we propose a method for modeling the transmission of the haplotypes from the closest genotyped relatives along an entire chromosome. The method relies on a hidden Markov model where hidden states correspond to the set of all possible origins of a haplotype within a given pedigree. Initial state probabilities...
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ژورنال
عنوان ژورنال: Genetics
سال: 2011
ISSN: 1943-2631
DOI: 10.1534/genetics.111.127720